CA2766082C – June 11, 2019 – USE OF ONE OR A COMBINATION OF PHYTO-CANNABINOIDS IN THE TREATMENT OF EPILEPSY

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Inventors :

WHALLEY, BEN; STEPHENS, GARY; WILLIAMS, CLAIRE; GUY, GEOFFREY; WRIGHT, STEPHEN; KIKUCHI, TETSURO

Owner :

GW PHARMA LIMITED

Application Number :

CA2766082

Document Number :

CA2766082C

Priority Date :

July 3, 2009

Filing Date :

June 29, 2010

Date of Grant/ Publication :

June 11, 2019

Class :

A61K31 / 05; A61K31 / 352; A61P25 / 08

Abstract

This invention relates to the use of one or more cannabinoids in the treatment of epilepsy and more particularly to the use of one or a combination of cannabinoids in the treatment of generalized or partial seizure. In one embodiment it relates to the use of the cannabinoid THCV, as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In another embodiment the phytocannabinoid is CBD.

Claim(s)

1. Cannabidiol (CBD) for use in the treatment of partial seizurewherein theCBD is present in an amount which provides a daily dose of at least 400mg.;
2. CBD for use in the treatment ofpartial seizureas claimed in claim 1 wherein the CBD is present in an amount which provides a daily dose of from 400 to 800mg.;
3. CBD for use in the treatment of partial seizure as claimed in any of the preceding claims, wherein the partial seizure hasdeveloped into a most severe seizure.;
4. CBD for use in the treatment of partial seizure as claimed in claim 3, wherein the most severe seizure is a tonic-clonic seizure.;
5. CBD for use in the treatment of partial seizure as claimed in any of the preceding claims wherein the CBD is used in combination with THCV.;
6. CBD for use in the treatment of partial seizure as claimed in claim 5, wherein the THCV is present in an amount which provides a daily dose of at least 1.5 mg.;
7. CBD for use in the treatment of partial seizure as claimed in claim 6, wherein the THCV is present in an amount which provides a daily dose of at least 15 mg.;
8. CBD for use in the treatment of partial seizure as claimed in any of claims 1 to 4, or in combination with THCV as claimed in any of claims 5 to 7, wherein the CBD alone or in combination with THCV is present as a plant extract.;
9. CBD for use in the treatment of partial seizure as claimed in claim 8, wherein the plant extract comprises less than 5% by weight of tetrahydrocannabinol (THC) as a percentage of any cannabinoids present in the plant extract.;
10. CBD for use in the treatment of partial seizure as claimed in claim 9, wherein the plant extract comprises less than 1% by weight of tetrahydrocannabinol (THC) as a percentage of any cannabinoids present in the plant extract.;
11. CBD for use in the treatment of partial seizure as claimed in any of claims 1 to 4, alone or in combination with THCV as claimed in any of claims 5 to 7, wherein the CBD alone or in combination with THCV is present as a pure or isolated cannabinoid.;
12. A composition for use in treating partial seizure comprising cannabidiol (CBD).;
13. Cannabidiol (CBD)for use in the manufacture of a medicament for use in the treatment of partial seizure.;
14. A method of treatingpartial seizure comprising administering to a patient a medicament comprising an effective amount of CBD.

Summary

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