US10220005B2 – March 5, 2019 – Synergistic therapies of cannabidiol with hypothermia for neuroprotection

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Inventors :

Jose Martinez-Orgado; Geoffrey Guy

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Priority Date :

June 8, 2012

Filing Date :

June 10, 2013

Date of Grant/ Publication :

March 5, 2019

Class :

; A61F7 / 00; A61K31 / 05; A61K36 / 185; A61F7 / 02


The present invention relates to a method of treating newborn hypoxic-ischemic encephalopathy (NHIE). Such method comprises administering the phytocannabinoid cannabidiol (CBD) in combination with therapeutic hypothermia to a newborn subject suffering from NHIE. Preferably the CBD is in the form of a plant extract, alternatively the CBD is in a pure or isolated form.


1. A method for treatment of newborn hypoxic-ischemic encephalopathy (NHIE) comprising administering to a newborn human suffering from NHIE a combination of cannabidiol (CBD) with therapeutic hypothermia, wherein the CBD is a non-CB1 agonist.


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