US10227308B2 – March 12, 2019 – Radiolabeled cannabinoid receptor 2 ligand

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Inventors :

Simon M. Ametamey; Juergen Fingerle; Luca Gobbi; Uwe Grether; Ahmed Haider; Thomas Hartung; Linjing Mu; Leo Nicholls; Mark Rogers-Evans; Christoph Ullmer

Owner :

F.HOFFMANN-LA ROCHE AG, SWITZERLAND F.HOFFMANN-LA ROCHE AG, SWITZERLAND HOFFMANN-LA ROCHE INC., NEW JERSEY EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH, SWITZ UNIVERSITAT ZURICH, SWITZERLAND

Application Number :

US15443894

Document Number :

US10227308B2

Priority Date :

October 27, 2014

Filing Date :

February 27, 2017

Date of Grant/ Publication :

March 12, 2019

Class :

C07D231 / 40; G01N33 / 566; A61K51 / 04; C07B59 / 00; G01N33 / 60; G01N33 / 94

Abstract

The present invention relates to a compound of formula (I) wherein R 1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.

Claim(s)

1. A compound of formula (I) wherein R 1 is a methyl group and wherein at least one of the atoms of the methyl group of R 1 is replaced with a radionuclide independently selected from the group consisting of [ 3 H], [ 11 C] and [ 14 C].

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