US10246431B2 – April 2, 2019 – Process to extract and purify ?9-tetrahydrocannabinol

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Inventors :

Lekhram Changoer; Cornelis Herman Michel Van Der Loo; Erik Keller

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Application Number :


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Priority Date :

August 1, 2018

Filing Date :

August 1, 2018

Date of Grant/ Publication :

April 2, 2019

Class :

; A61K36 / 00; C07D311 / 80


? 9 -THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. ? 9 -THC carboxylic acid is converted to ? 9 -THC carboxylic salt before being extracted by a third organic solvent and converted back to ? 9 -THC carboxylic acid. Using a solvent swap, ? 9 -THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give ? 9 -THC.


1. A method of producing delta 9 -THC consisting essentially of: extracting delta 9 -THC carboxylic acid from cannabis flowers using heptane to obtain a heptane extract; filtering the heptane extract to remove solid plant matter; separating the delta 9 -THC carboxylic acid from the heptane extract by contacting the heptane extract with sodium chloride water adjusted to a pH range of 13.2 to 13.4 using an inorganic base to form a liquid mixture; stirring the liquid mixture; and leaving the liquid mixture to settle, wherein the liquid mixture forms three layers consisting of a first organic layer, a second oily layer, and third aqueous layer; and separating out the oily layer from the other two layers to yield the delta 9 -THC.


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