US10265293B2 – April 23, 2019 – Oral cannabinoid formulations

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Inventors :

Venkat R. Goskonda; Ashok Chavan; Amit Kokate; Howard Gill

Owner :

INSYS DEVELOPMENT COMPANY, INC.

Application Number :

US15132896

Document Number :

US10265293B2

Priority Date :

April 19, 2016

Filing Date :

April 19, 2016

Date of Grant/ Publication :

April 23, 2019

Class :

; A61K31 / 352; A61K9 / 08; A61K36 / 185; A61K9 / 00; A61K31 / 353; A61K47 / 10

Abstract

Oral cannabinoid formulations, including an aqueous-based oral dronabinol solution, that are stable at room or refrigerated temperatures and may possess improved in vivo absorption profiles with faster onset and lower inter-subject variability.

Claim(s)

1. A stable oral pharmaceutical solution comprising: (a) dronabinol at a concentration of about 0.54%; (b) alcohol at a concentration of about 15-65%; (c) a co-solvent consisting of propylene glycol, polyethylene glycol, or a mixture thereof at a concentration of about 17.5%; (d) an antioxidant; and (e) water in a concentration of less than 31.9%.

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