US10272125B2 – April 30, 2019 – Transdermal delivery of cannabidiol with other active moieties including cannabinoids

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Inventors :

Ludwig Weimann

Owner :

LIFE TECH GLOBAL, LLC

Application Number :

US15265823

Document Number :

US10272125B2

Priority Date :

September 14, 2016

Filing Date :

September 14, 2016

Date of Grant/ Publication :

April 30, 2019

Class :

; A61K9 / 70; A61K31 / 05; A61K31 / 352; A61K36 / 185; A61K47 / 10; A61K47 / 12; A61K47 / 32; A61K47 / 34; A61K47 / 38

Abstract

Transdermal delivery devices for the delivery of cannabidiol (CBD) and related moieties are shown and described. In a reservoir-patch design, a microporous, hydrophilic membrane and a backing define a reservoir that houses a mixture of CBD, a polar liquid, and a gelling agent. In a monolithic design, a release liner is coated with a mixture of CBD and a PIB or amine-compatible silicone skin adhesive laminated to the backing material. In using CBD as a pure compound or as one to combine with other moieties, the invention is able to control delivery better than the prior art.

Claim(s)

1. A transdermal monolithic patch comprising, a matrix comprising cannabidiol (CBD) in polyisobutylene (PIB) adhesive, and 1,2-propylene glycol; a release liner; and a backing, wherein the matrix has a first surface adhered to the backing, and a second surface opposite the surface adhered to the backing; wherein the release liner is adhered to the surface of the matrix opposite the surface adhered to the backing; wherein the CBD is present in the matrix at concentration from 1% to 30% by weight; wherein the CBD is dissolved in heptane or ethyl acetate; and wherein the matrix excludes ethanol.;
2. A transdermal monolithic patch comprising, a matrix comprising cannabidiol (CBD) in amine-compatible silicone adhesive and ethyl acetate, and 1,2-propylene glycol, wherein OH groups of the silicone are capped with methyl groups, wherein the CBD is present in the matrix at a concentration from 1% to 30% by weight, and wherein the matrix excludes oleic acid; a release liner; and a backing, wherein the matrix has a first surface adhered to the backing, and a second surface opposite the surface adhered to the backing; and wherein the release liner is adhered to the surface of the matrix opposite the surface adhered to the backing.;
3. A reservoir patch device for the transdermal delivery of cannabidiol and other moieties, comprising, in combination: a backing attached to a hydrophilic, porous membrane to define an enclosed reservoir between the backing and the hydrophilic, porous membrane, wherein the porous membrane has a first side with a skin adhesive and a second side facing the interior of the reservoir; a preparation comprising a therapeutically effective amount of cannabidiol (CBD) and an organic polar liquid carrier contained in the reservoir, wherein the polar liquid carrier excludes either ethanol or oleic acid, wherein the preparation includes tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THC-a), cannabinol (CBN), and cannabichromene (CBC); a release liner attached to the first side of the hydrophilic porous membrane, wherein the release liner is selectively removable from the first side of the hydrophilic porous membrane to expose the skin adhesive, wherein said hydrophilic porous membrane is capable of providing a monotonically increasing cumulative flux of CBD through cadaver skin, which at about 17 hours is 700 micrograms CBD per cm 2 .;
11. A monolithic patch device for the transdermal delivery of cannabidiol (CBD), comprising: a backing; a matrix that comprises a mixture of an adhesive and a therapeutically effective amount of cannabidiol coated on the backing, wherein the adhesive comprises a amine-compatible silicone adhesive in ethyl acetate with a solids content of 60 percent by weight and a viscosity of 1200 mPa-s at 20 degrees C., and the mixture has a first surface adhered to the backing and a second, skin-adhering surface; wherein what is excluded is silicone adhesive polymer that has over 1 free hydroxyl groups per 100 atoms of the adhesive polymer, a release liner removably attached to the second, skin adhering surface of the mixture, and wherein the amine-compatible silicone adhesive comprises trimethylsiloxy end groups that are substantially non-reactive with amines, and wherein 25% of the matrix by weight comprises a cannabis extract oil that comprises 45.3 percent CBD and 33.5 percent THC, and wherein 75% of the matrix by weight is the amine-compatible silicone adhesive, wherein the matrix comprises 1,2-propylene glycol.;
14. A device for the transdermal delivery of cannabidiol (CBD), comprising: a backing; a release liner; a mixture of an adhesive and a therapeutically effective amount of cannabidiol coated on the release liner, wherein the mixture includes tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THC-a), cannabinol (CBN), and cannabichromene (CBC); wherein the adhesive consisting essentially of a polyisobutylene adhesive not in mineral oil having a viscosity-average molecular weight ranging from about 30,000 Daltons to about 70,000 Daltons, and the mixture has a first surface adhered to the backing and a second, skin-adhering surface to which the release liner is removably adhered, wherein the device excludes ethanol, and wherein the cannabidiol is dissolved in heptane or ethyl acetate.

Summary

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