US10272172B2 – April 30, 2019 – Multifunctional transdermal dressing for wounds

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Inventors :

Krishnaswamy Kasthuri Rangan; Tirumalai Srinivas Sudarshan

Owner :

MATERIALS MODIFICATION INC., VIRGINIA

Application Number :

US15345122

Document Number :

US10272172B2

Priority Date :

November 7, 2016

Filing Date :

November 7, 2016

Date of Grant/ Publication :

April 30, 2019

Class :

; A61L15 / 18; A61L15 / 44; A61K33 / 38; A61K31 / 167; A61F13 / 00; A61K31 / 4468; A61L15 / 46

Abstract

A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.

Claim(s)

1. A method of preparing a multifunctional polymer-free clay film comprising a clay, an antimicrobial agent, a zwitterion and an analgesic, the method comprising: a) mixing a clay, the antimicrobial agent and water to form a first slurry; b) centrifuging and washing the first slurry of step a) with water to obtain a washed second slurry; c) adding a zwitterion and water to the washed second slurry of step b) to obtain a third slurry; d) casting the third slurry of step c) onto a substrate to obtain a first dried product; e) adding drops of the analgesic in a non-aqueous solvent onto the first dried product of step d) to obtain a resultant product, f) drying the resultant product to obtain a second dried product; and, g) separating the second dried product of step f) from the substrate of step d), wherein the second dried product of steps f) and g) is the multifunctional polymer-free clay film which provides both antimicrobial and pain relieving properties, wherein the zwitterion is selected from the group consisting of N,N,N-trimethylglycine and N,N,N-trimethylglycine hydrochloride, and wherein the antimicrobial agent in the multifunctional polymer-free clay film is selected from the group consisting of silver ion, copper, silver-containing compounds, and, copper containing compounds.

Summary

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