US10292942B2 – May 21, 2019 – Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux

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Inventors :

Michael Horstmann; Mohammad Sameti; Tobias Jung

Owner :

LTS LOHMANN THERAPIE-SYSTEME AG, GERMANY

Application Number :

US12302065

Document Number :

US10292942B2

Priority Date :

June 8, 2006

Filing Date :

May 30, 2007

Date of Grant/ Publication :

May 21, 2019

Class :

; A61K9 / 70

Abstract

The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Claim(s)

1. A transdermal therapeutic system with an active ingredient-containing matrix comprising an essentially water-insoluble base material having inclusion bodies which are separated from one another, said inclusion bodies formed from water-soluble or water-swellable material containing active ingredient particles dispersed inside or suspended inside said water-soluble or water-swellable material, wherein said active ingredient particles are micro- or nanoparticles, said active ingredient, in the state prior to the application of the transdermal therapeutic system to the skin, is neither liquid nor dispersed or suspended in liquid, the active ingredient particles have a size that is less than 20% of the particle size of the inclusion bodies, and the active ingredient has a melting point above 50° C.;
20. A transdermal therapeutic system with an active ingredient-containing matrix, said matrix consisting of water-insoluble base material having inclusion bodies separated from one another, said inclusion bodies consisting of water-soluble or water-swellable material and active ingredient particles inside said water-soluble or water-swellable material, wherein said active ingredient particles are micro- or nanoparticles and said active ingredient, in the state prior to the application of the 7 S transdermal therapeutic system to the skin, is neither liquid nor dispersed or suspended in liquid, said base material optionally further consisting of plasticizers, tackifiers, absorption promoters, stabilizers, fillers, modifiers having a micellar action or phase formers, and said transdermal therapeutic system does not include a layer which limits the access of moisture from the skin.

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