US10307397B2 – June 4, 2019 – Oral dissolvable film that includes plant extract

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Inventors :

Eric Allen; Robert Davidson; Tony LaRosa; David Reid

Owner :

CONCEPT MATRIX SOLUTIONS, CALIFORNIA CONCEPT MATRIX SOLUTIONS, CALIFORNIA CURE PHARMACEUTICAL HOLDING CORP., CALIFORNIA

Application Number :

US14810595

Document Number :

US10307397B2

Priority Date :

July 28, 2015

Filing Date :

July 28, 2015

Date of Grant/ Publication :

June 4, 2019

Class :

; A61K36 / 185; A61K36 / 534; A61K31 / 366; A61K36 / 67; A61K31 / 05; A61K31 / 352; A61K9 / 00; A61K45 / 06; A61K9 / 70; A61K9 / 127

Abstract

Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Claim(s)

1. An oral dissolvable thin film comprising effective amounts of: (a) water; (b) a binder selected from the group consisting of pectin, microcrystalline cellulose, and combinations thereof; (c) a lipid, wherein the lipid comprises cocoa butter and lecithin; (d) an emulsifier, wherein the emulsifier comprises glycerin; (e) at least one cannabinoid, present in an amount of at least about 30 wt. % of the oral dissolvable thin film; (f) a flavoring agent selected from the group consisting of mint flavoring, spearmint flavoring, peppermint flavoring, and combinations thereof; (g) a sweetener selected from the group consisting of sucralose, acesulfame potassium, and combinations thereof; and (h) a powder coating on at least one external surface of the oral dissolvable thin film wherein: at least about 10 wt. % of the at least one cannabinoid is encapsulated by the lipid, the oral dissolvable thin film has a thickness of about 0.01 mm to about 20 mm, and the oral dissolvable thin film has a rapid dissolution of about 30-300.;
13. An oral dissolvable thin film comprising effective amounts of: (a) about 2 wt. % to 24 wt. % of water; (b) about 40 wt. % to 50 wt. % of a binder selected from the group consisting of pectin, microcrystalline cellulose, and combinations thereof; (c) about 0.1 wt. % to 22 wt. % of a lipid, wherein the lipid comprises cocoa butter and lecithin; (d) about 3 wt. % to 22 wt. % of an emulsifier, wherein the emulsifier comprises glycerin; (e) at least about 30 wt. % of at least one cannabinoid; (f) greater than 0 wt. % to about 10 wt. % of a flavoring agent selected from the group consisting of mint flavoring, spearmint flavoring, peppermint flavoring, and combinations thereof; (g) greater than 0 wt. % to about 40 wt. % of a sweetener selected from the group consisting of sucralose, acesulfame potassium, and combinations thereof; (h) greater than 0 wt. % to about 20 wt. % of a powder coating, wherein powder coating is present on at least one external surface of the oral dissolvable thin film; and (i) a preservative; wherein: at least about 10 wt. % of the at least one cannabinoid is encapsulated by the lipid, the oral dissolvable thin film has a thickness of about 0.01 mm to about 20 mm, the oral dissolvable thin film has a rapid dissolution of about 30-300, and the at least one cannabinoid comprises less than about 1 wt. % plant waxes, less than about 1 wt. % plant lipids, less than about 1 wt. % plant pigments, less than about 1 wt. % chlorophylls.

Summary

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