US10328092B2 – June 25, 2019 – Methods and compositions for treatment of drug addiction

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Inventors :

David Stellwagen; Gil Moshe Lewitus

Owner :

THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN

Application Number :

US15178138

Document Number :

US10328092B2

Priority Date :

June 9, 2016

Filing Date :

June 9, 2016

Date of Grant/ Publication :

June 25, 2019

Class :

A61K31 / 7028; A61P25 / 30; A61P25 / 32; A61P25 / 34; A61P25 / 36

Abstract

Methods of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and/or reducing development of behavioral sensitization or suppressing drug induced behavioral sensitization in a subject, optionally a subject that is afflicted with an addiction, the method comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist or a composition comprising said TLR4 agonist, preferably wherein the TLR4 agonist is a monophosphoryl lipid A (MPLA).

Claim(s)

1. A method of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and reducing development of behavioural sensitization or suppressing drug induced behavioural sensitization in a subject, optionally a subject that is afflicted with an addiction, comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist as active substance or a composition comprising said TLR4 agonist as active substance.

Summary

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