US10376586B2 – August 13, 2019 – Method and compositions for solubilizing non-polar constituents

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Inventors :

Michael V. Zumpano

Owner :

Entourage Bioscience, LLC

Application Number :

US15433649

Document Number :

US10376586B2

Priority Date :

February 15, 2017

Filing Date :

February 15, 2017

Date of Grant/ Publication :

August 13, 2019

Class :

A61K31 / 05; A61K47 / 14; A61K9 / 00; C07D475 / 02; C07D239 / 42; A24B15 / 16; A61M15 / 00

Abstract

A method for solubilizing non-polar target compounds into a carrier liquid is described. A carrier oil, such as a MCT, or a mixture of MCTs, may be used to solubilize non-polar target compounds. The carrier oil may also include one or more buffers for stability of the target compounds within the carrier oil.

Claim(s)

1. A method for solubilizing cannabidiol, the method comprising: admixing cannabidiol and a medium chain triglyceride carrier liquid comprised of at least one of 0-6.0% of the triglyceride form of hexanoic acid, 6.0-60% of the triglyceride form of octanic acid, and 6.0-60% of the triglyceride form of decanoic acid to form an azeotropic solution; adding an amount of buffer to the carrier liquid; and heating the azeotropic solution in a heated vaporization delivery system to vaporize the azeotropic solution.;
12. A composition for use in an electronic nicotine delivery system, the composition comprising: a non-polar target compound, the non-polar target compound comprising at least one of cannabidiol, riboflavin, and sulbutiamine; a carrier liquid comprised of one or more medium chain triglycerides comprised of at least one of about 0-6.0% of the triglyceride form of hexanoic acid, about 6.0-60% of the triglyceride form of octanic acid, and about 6.0-60% of the triglyceride form of decanoic acid; at least one buffer having a molar concentration of around 0.01-10 mM in the carrier liquid; and an oil miscible anti-oxidant.;
16. A vapor cartridge for use in a heated vaporization system, the vapor cartridge containing a composition comprising: a non-polar target compound, the non-polar target compound comprising at least one of cannabidiol, riboflavin, and sulbutiamine; at least one buffer; and a carrier liquid comprised of one or more medium chain triglycerides comprised of at least one of the triglyceride forms of 0-6.0% hexanoic acid, 6.0-60% octanic acid, and 6.0-60% decanoic acid.

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