US20190030133A1 – January 31, 2019 – DIKETOPIPERAZINE SALTS FOR DRUG DELIVERY AND RELATED METHODS

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Inventors :

Andrea Leone-Bay; Destardi Moye-Sherman; Bryan R. Wilson

Owner :

MANNKIND CORPORATION

Application Number :

US16151766

Document Number :

US20190030133A1

Priority Date :

October 4, 2018

Filing Date :

October 4, 2018

Date of Grant/ Publication :

January 31, 2019

Class :

A61K38 / 28; C07D241 / 08; A61K9 / 16; A61K31 / 4965; A61K9 / 00; A61K9 / 48; A61K31 / 535; A61K47 / 22; C07D241 / 02; A61K31 / 357

Abstract

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.

Claim(s)

1 . A method of preparing a solid composition for drug delivery comprising: preparing a solution containing a biologically active agent and a pharmaceutically-acceptable salt of a heterocyclic compound in a solvent; and a step for removing said solvent; wherein said pharmaceutically acceptable salt of a heterocyclic compound has the structure according to Formula 1: wherein R 1 or R 2 comprise at least one carboxylate functional group; E 1 and E 2 are NH 2 ; and said salt further comprises at least one cation.

Summary

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