US20190144414A1 – May 16, 2019 – METHOD FOR PURIFYING CANNABINOID COMPOUNDS

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Inventors :

Harry ERFURT; Maria WEBER; Hans-Jürgen NIEMEYER; Marcus Rudolf GÖTZ; Matthias WINKLER

Owner :

SYMRISE AG

Application Number :

US16300205

Document Number :

US20190144414A1

Priority Date :

May 13, 2016

Filing Date :

May 13, 2016

Date of Grant/ Publication :

May 16, 2019

Class :

; C07D311 / 80; C07C67 / 343; C07C37 / 00; C07C67 / 02; B01D15 / 18

Abstract

The present invention relates to methods for purifying one or two cannabinoid compounds using simulated moving bed chromatography, wherein the cannabinoid compound(s) is/are obtained in the extract and/or the raffmate with the total amount of isomeric impurities being below detection level. In particular, the present invention relates to methods for the purification of cannabidiol, trans-(?)-delta-9-tetrahydrocannabinol, cannabidivarin, trans-(?)-delta-9-tetrahydrocannabivarin and cannabigerol which have been obtained by enantiopure synthesis.

Claim(s)

1 . A method for purifying one or two cannabinoid compounds comprising: i) providing a mixture comprising at least one cannabinoid compound obtained by enantiopure synthesis and one or more of its isomers and optionally one or more further organic compounds, and ii) simultaneously, a) continuously feeding the mixture of step i) through a feed port into a simulated moving bed chromatographic apparatus comprising at least four columns connected in series and containing a stationary phase, and b) continuously feeding eluant into the apparatus through an eluant port, and c) continuously withdrawing the extract through an extract port, and d) continuously withdrawing the raffinate through a raffinate port, wherein the extract and/or the raffinate respectively comprise(s) one purified cannabinoid compound and wherein the extract and/or the raffinate comprising one purified cannabinoid compound comprise(s) less than 100 ppm in total of any isomer(s) of the purified cannabinoid compound present in step i).

Summary

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