US20190282502A1 – September 19, 2019 – ENCAPSULATION OF LIPOPHILIC INGREDIENTS IN DISPERSIBLE SPRAY DRIED POWDERS SUITABLE FOR INHALATION

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Inventors :

Andrew John Boeckl; David Edward Cookson

Owner :

Flurry Powders, LLC

Application Number :

US16432200

Document Number :

US20190282502A1

Priority Date :

June 5, 2019

Filing Date :

June 5, 2019

Date of Grant/ Publication :

September 19, 2019

Class :

A61K9 / 16; A61K31 / 352

Abstract

A method of manufacturing a flowable and dispersible powder includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

Claim(s)

1 . A method of manufacturing a flowable and dispersible powder, the method comprising: mixing an insoluble or slightly soluble substance into a terpene to form a suspension; adding at least one functional excipient to water to form an aqueous solution; dispersing the suspension into the aqueous solution using one or both of a homogenizer or an ultrasonic device to form a coarse emulsion; treating the coarse emulsion with one or both of the ultrasonic device or a high shear device to form a nanoemulsion; and spray drying the nanoemulsion, thereby evaporating at least a portion of the terpene and substantially all the water to form a dry powder formed from solid particles comprising the insoluble or slightly soluble substance.;
9 . A method of manufacturing a flowable and dispersible powder, the method comprising: mixing an insoluble or slightly soluble substance into a terpene to form a suspension, wherein the insoluble or slightly soluble substance comprises a cannabinoid; adding at least one functional excipient to water to form an aqueous solution; dispersing the suspension into the aqueous solution using one or both of a homogenizer or an ultrasonic device to form a coarse emulsion; treating the coarse emulsion with one or both of the ultrasonic device or a high shear device to form a nanoemulsion; and spray drying the nanoemulsion, thereby evaporating at least a portion of the terpene and substantially all the water to form a dry powder formed from solid particles comprising the substance, wherein the dry powder comprises between about 1% and 60% by weight of the cannabinoid.;
17 . A flowable dry powder composition, comprising: an insoluble or slightly soluble component; and one or more of a hydrophobic amino acid, a disaccharide, a oligosaccharide, a surfactant, an emulsifier, a stabilizing additive, or a bulking agent, wherein: the dry powder composition has a moisture content below about 10% by weight water; and the dry powder composition comprises between about 0.01% and 50% w/w of the insoluble or slightly soluble component.

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