US20190314276A1 – October 17, 2019 – METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT

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Inventors :

Bryan R. Wilson; Marshall Grant

Owner :

Mannkind Corporation

Application Number :

US16453875

Document Number :

US20190314276A1

Priority Date :

June 26, 2019

Filing Date :

June 26, 2019

Date of Grant/ Publication :

October 17, 2019

Class :

A61K9 / 00; A61K38 / 28; A61K9 / 14; A61K9 / 16

Abstract

Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.

Claim(s)

claim 1: 1 . An inhalable dry powder with an improved pharmaceutic property comprising microparticles of a diketopiperazine combined with an active agent wherein the pharmaceutic property are improved by increasing the density of powder, increasing the aerodynamic performance of powder, or improving the stability of the active agent and optionally, one or more pharmaceutically acceptable carriers.

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