US20190314309A1 – October 17, 2019 – KIT, COMPOSITION, AND COMBINATION THERAPY FOR FRAGILE X SYNDROME

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Inventors :

David Brown

Owner :

HEALX LIMITED

Application Number :

US16383037

Document Number :

US20190314309A1

Priority Date :

April 12, 2019

Filing Date :

April 12, 2019

Date of Grant/ Publication :

October 17, 2019

Class :

A61K31 / 192; A61K9 / 00; A61K31 / 437; A61K31 / 135; A61K31 / 353; A61K31 / 05; A61K31 / 65; A61K31 / 35

Abstract

Described herein are kits, compositions, and combination therapies comprising sulindac for use in the treatment of fragile X syndrome (FXS).

Claim(s)

claim 1: 5 – 17 . (canceled);
claim 2: 18 . A kit comprising: (i) sulindac, or a pharmaceutically acceptable salt thereof; and (ii) Compound A, or a pharmaceutically acceptable salt thereof, wherein Compound A is selected from the group consisting of: minocycline, doxycycline, lovastatin, metformin, epigallocatechin gallate, lithium, tideglusib, lamotrigine, acamprosate, ganaxolone, basimglurant, mavoglurant, methylphenidate, L-carnitine, L-acetyl carnitine, zardaverine, ibudilast, metoprolol, penbutolol, fasudil, carbamazepine, midostaurin, sildenafil, tadalafil, gabapentin, stiripentol, ganaxolone, donepezil tetracyclines, cannabidiol, curcumin, simvastatin, atorvastatin, pravastatin, fluvastatin, rosuvastatin, pitavastatin, apigenin, telmisartan, medium and long chain fatty acids, indirubin, pregabalin, baclofen, arbaclofen, memantine, ethchlorvynol, fenobam, riluzole, crisaborole, S-rolipram, apremilast, cilomilast, roflumilast, dipyridamole, drotaverine, propentofylline, caffeine, papaverine, trapidil, flavoxate, amlexano X, pentoxifylline, propanolol, pindolol, acebutalol, bisoprolol, carvedilol, labetalol, metipranolol, oxprenalol, pindolol, tertatolol, timolol, topiramate, tianeptine, quercetin, disulfiram, imatinib, gefitinib, selumetinib, refametinib, fusidic acid, sertraline, lorazepam, phenobarbital, vardenafil, udenafil, avanafil, ruxolitinib, momelotinib, bortezomib, carfilzomib, carnosol, riluzole, luteolin, carnosic acid, resveratrol, methylphenidate, menadione, taurine, niacin, clorazepic acid, diazepam and other ‘azepam’ class drugs, chlordiazepoxide, staurosporin, gaboxadol, progabide, tulrampator, ketamine, decanoic acid, piracetam, pramiracetam, dexmethylphenidate, oglemilast, levetiracetam and vigabatrin.;
claim 3: 19 – 21 . (canceled);
claim 4: 22 . A composition comprising: (i) sulindac, or a pharmaceutically acceptable salt thereof; and (ii) Compound A, or a pharmaceutically acceptable salt thereof, wherein Compound A is selected from the group consisting of: minocycline, doxycycline, lovastatin, metformin, epigallocatechin gallate, lithium, tideglusib, lamotrigine, acamprosate, ganaxolone, basimglurant, mavoglurant, methylphenidate, L-carnitine, L-acetyl carnitine, zardaverine, ibudilast, metoprolol, penbutolol, fasudil, carbamazepine, midostaurin, sildenafil, tadalafil, gabapentin, stiripentol, donepezil, tetracyclines, cannabidiol, curcumin, simvastatin, atorvastatin, pravastatin, fluvastatin, rosuvastatin, pitavastatin, apigenin, telmisartan, medium and long chain fatty acids, indirubin, pregabalin, baclofen, arbaclofen, memantine, ethchlorvynol, fenobam, riluzole, crisaborole, S-rolipram, apremilast, cilomilast, roflumilast, dipyridamole, drotaverine, propentofylline, caffeine, papaverine, trapidil, flavoxate, amlexano X, pentoxifylline, propanolol, pindolol, acebutalol, bisoprolol, carvedilol, labetalol, metipranolol, oxprenalol, pindolol, tertatolol, timolol, topiramate, tianeptine, quercetin, disulfiram, imatinib, gefitinib, selumetinib, refametinib, fusidic acid, sertraline, lorazepam, phenobarbital, vardenafil, udenafil, avanafil, ruxolitinib, momelotinib, bortezomib, carfilzomib, carnosol, riluzole, luteolin, carnosic acid, resveratrol, methylphenidate, menadione, taurine, niacin, clorazepic acid, diazepam and other ‘azepam’ class drugs, chlordiazepoxide, staurosporin, gaboxadol, progabide, tulrampator, ketamine, decanoic acid, piracetam, pramiracetam, dexmethylphenidate, oglemilast, levetiracetam and vigabatrin.;
claim 5: 23 . (canceled);
claim 6: 24 . A method of treating fragile x syndrome in a subject in need thereof comprising administering to the subject simultaneously, separately or sequentially: (i) sulindac, or a pharmaceutically acceptable salt thereof; and (ii) Compound A, or a pharmaceutically acceptable salt thereof, wherein Compound A is selected from the group consisting of: minocycline, doxycycline, lovastatin, metformin, epigallocatechin gallate, lithium, tideglusib, lamotrigine, acamprosate, ganaxolone, basimglurant, mavoglurant, methylphenidate, L-carnitine, L-acetyl carnitine, zardaverine, ibudilast, metoprolol, penbutolol, fasudil, carbamazepine, midostaurin, sildenafil, tadalafil, gabapentin, stiripentol, ganaxolone, donepezil, tetracyclines, cannabidiol, curcumin, simvastatin, atorvastatin, pravastatin, fluvastatin, rosuvastatin, pitavastatin, apigenin, telmisartan, medium and long chain fatty acids, indirubin, pregabalin, baclofen, arbaclofen, memantine, ethchlorvynol, fenobam, riluzole, crisaborole, S-rolipram, apremilast, cilomilast, roflumilast, dipyridamole, drotaverine, propentofylline, caffeine, papaverine, trapidil, flavoxate, amlexano X, pentoxifylline, propanolol, pindolol, acebutalol, bisoprolol, carvedilol, labetalol, metipranolol, oxprenalol, pindolol, tertatolol, timolol, topiramate, tianeptine, quercetin, disulfiram, imatinib, gefitinib, selumetinib, refametinib, fusidic acid, sertraline, lorazepam, phenobarbital, vardenafil, udenafil, avanafil, ruxolitinib, momelotinib, bortezomib, carfilzomib, carnosol, riluzole, luteolin, carnosic acid, resveratrol, methylphenidate, menadione, taurine, niacin, clorazepic acid, diazepam and other ‘azepam’ class drugs, chlordiazepoxide, staurosporin, gaboxadol, progabide, tulrampator, ketamine, decanoic acid, piracetam, pramiracetam, dexmethylphenidate, oglemilast, levetiracetam and vigabatrin.;
claim 7: 25 – 29 . (canceled)

Summary

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