US20190321611A1 – October 24, 2019 – INNER EAR DRUG DELIVERY DEVICES AND METHODS OF USE

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Inventors :

Kevin W. Sacherman; Signe Erickson; Hugo Peris; Eugene de Juan, JR.

Owner :

SPIRAL THERAPEUTICS, INC.

Application Number :

US16388159

Document Number :

US20190321611A1

Priority Date :

April 18, 2019

Filing Date :

April 18, 2019

Date of Grant/ Publication :

October 24, 2019

Class :

A61M31 / 00; A61M37 / 00

Abstract

An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.

Claim(s)

1 . An implantable device for delivering a therapeutic agent to treat an ear of a patient, the device comprising: a body having a distal end region and a proximal end region, wherein the body defines, at least in part, a reservoir configured to contain the therapeutic agent; and a shaft attached to the distal end region of the body and comprising a lumen extending through the shaft, the lumen having at least one inlet at a proximal end region of the shaft in fluid communication with the reservoir and at least one outlet at a distal end region of the shaft, the shaft having a length between the proximal end region and the distal end region, wherein, upon implantation of the body in a region of the ear, the length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear, and wherein the device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion.;
28 . An implantable device for delivering a therapeutic agent to treat an ear of a patient, the device comprising: a body having a distal end region and a proximal end region, the body configured to be implanted in a cavity of a middle ear of the patient, wherein the body defines, at least in part, a reservoir configured to contain the therapeutic agent; a shaft attached to the distal end region of the body and comprising: a lumen extending through the shaft, the lumen having at least one inlet at a proximal end region of the shaft in fluid communication with the reservoir and at least one outlet at a distal end region of the shaft, such that when the body is implanted in the cavity, the shaft extends through a wall of the cavity and the at least one outlet is positioned into a cochlear space; and a helical thread-form on an outer surface of the shaft configured to cut through and linearly advance into the wall upon rotation, wherein the device is configured to deliver the therapeutic agent from the reservoir via passive diffusion through the at least one outlet of the shaft into the perilymph of the cochlear space.

Summary

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