WO2019023668A1 – January 31, 2019 – CANNABINOID COMPOSITION HAVING AN OPTIMIZED FATTY ACID EXCIPIENT PROFILE

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Inventors :

SHAABAN, Basil Adil - 730 17th Street, Suite 420, Denver, Colorado 80202

Owner :

SHAABAN, Basil Adil

Application Number :

WOUS18044226

Document Number :

WO2019023668A1

Priority Date :

January 1, 1970

Filing Date :

July 27, 2018

Date of Grant/ Publication :

January 31, 2019

Class :

A61K31 / 353; A61K36 / 185; A61K47 / 12; A61K47 / 44

Abstract

A composition of matter for enhancing delivery of bioactive compounds, particularly cannabinoids into the human and animal organisms. The invention enhanced oral, transmucosal and transdermal delivery of a bioactive compound including cannabinoids through the use of an excipient having a desired ratio of fatty acids. The invention particularly includes a lipophilic phytocannabinoid such as THC or CBD, and an excipient fatty acid profile including palmitoleic acid and fatty acids selected from the group consisting of oleic acid and palmitic acid, and combinations thereof in optimal ratios. Macadamia nut oil is a preferred excipient having the desired lipid profile. Macadamia nut oil is a non-toxic plant oil, offers oxidation resistance to the fatty acids and cannabinoids to improve product shelf life, and has a sufficiently low melting temperature to remain liquid while refrigerated to further enhance product shelf life without changing the product phase from a liquid to a solid.

Claim(s)

1. A cannabinoid composition comprising: at least one cannabinoid derived from Cannabis sativa L; palmitoleic acid, and the ratio of palmitoleic acid to the at least one cannabinoid is between 1: 19 to 1000: 1.;
2. The cannabinoid composition as set forth in claim 1, further comprising: palmitic acid, wherein the ratio of palmitic acid to the at least one cannabinoid is between 1: 100 to 1000: 1.;
3. The cannabinoid composition as set forth in claim 2, wherein; the cannabinoid composition includes at least 5% of palmitoleic acid on a w:w basis.;
4. The cannabinoid composition as set forth in claim 2, further comprising: oleic acid, wherein the ratio of oleic acid to the at least one cannabinoid is between 1: 100 to 1000: 1.;
5. A cannabinoid composition comprising: at least one classical cannabinoid; an excipient; and the excipient includes fatty acids comprising at least 5% palmitoleic acid, at least 1% oleic acid, and at least 1% palmitic acid of the cannabinoid composition on a weight to weight basis.;
6. The cannabinoid composition as set forth in claim 5, wherein the at least 5% palmitoleic acid, at least 1% oleic acid and at least 1% palmitic acid are derived solely from macadamia nut oil.;
7. The cannabinoid composition as set forth in claim 5, wherein the at least 5% palmitoleic acid, at least 1% oleic acid, and at least 1% palmitic acid are derived solely from sea buckthorn oil.;
8. The cannabinoid composition as set forth in claim 5, wherein the at least 5% palmitoleic acid, at least 1% oleic acid, and at least 1% palmitic acid are derived from any combination of macadamia nut oil and sea buckthorn oil.;
9. The cannabinoid composition as set forth in claim 5, wherein the at least 5% palmitoleic acid, at least 1% oleic acid, and at least 1% palmitic acid are derived from one or more macadamia nut oil similes.;
10. The cannabinoid composition as set forth in claim 5, wherein the at least 5% palmitoleic acid, at least 1% oleic acid and at least 1% palmitic acid are derived from one or more sea buckthorn oil similes.;
11. The cannabinoid composition of claim 5, wherein the cannabinoid composition includes cannabinoids having a concentration of at least 0.1% of the composition on a weight to weight basis and the ratio of the excipient fatty acids to the cannabinoids is at least 3:2.;
12. The cannabinoid composition of claim 5, wherein the ratio of cannabinoids to palmitoleic acid is within the range of 1 : 1000 to 19: 1.;
13. The cannabinoid composition of claim 5, wherein the ratio of the cannabinoids to each of the palmitic acid and oleic acid is within the range of 1 : 1000 to 100: 1.;
14. A cannabinoid composition comprising: a whole plant extract of Cannabis sativa L. ; an omega-7 fatty acid in a concentration of at least 5% on a weight to weight basis of the composition; and a fatty acid in a concentration of at least 1% on a weight to weight basis of the composition selected from the group consisting of palmitic acid, oleic acid, and combinations thereof.;
15. The cannabinoid composition as set forth in claim 14, wherein the omega-7 fatty acid is palmitoleic acid.;
16. The cannabinoid composition as set forth in claim 15 wherein the palmitoleic acid is derived from macadamia nut oil.;
17. A bioactive composition comprising: at least one nutraceutical compound; palmitoleic acid, wherein the ratio of palmitoleic acid to the at least one nutraceutical compound in the bioactive composition is between 1: 19 to 1000: 1 on a weight to weight basis; palmitic acid, wherein the ratio of palmitic acid to the at least one nutraceutical compound in the bioactive composition is between 1 : 100 to 1000: 1 on a weight to weight basis; and oleic acid, wherein the ratio of the oleic acid to the at least one nutraceutical compound in the bioactive composition is between 1: 100 to 1000: 1 on a weight to weight basis.;
18. The bioactive composition as set forth in claim 17, wherein the nutraceutical compound is a cannabinoid and the bioactive composition includes; at least one essential oil selected from the group consisting of Anise, Basil, Bergamot, Cannabis, Cardamom, Chamomile, Cinnamon, Cocoa, Cypress, Eucalyptus, Fennel, Frankincense, Geranium, Ginger, Ginkgo Biloba, Gotu Kola, Grapefruit, Hemp, Jasmine, Lavender, Lavandin, Lemon, Lemon Verbena, Lemongrass, Lime, Marjoram, Neroli, Nutmeg, Orange, Oregano, Peppermint, Pepper, Pine, Ravintsara, Rose, Rosemary, Sage, Spearmint, Tea Tree, Thyme, Turmeric, Vanilla, Ylang Ylang, and any other therapeutic plant essential oils, and combinations thereof, including any of one or more of the monoterpenes, sequiterpenes and/or diterpenes, and/or their alcohols, and/or aldehydes and/or esters normally found in any therapeutic plant essential oil, and combinations thereof.;
19. The bioactive composition as set forth in claim 17, wherein the nutraceutical compound includes; at least one essential oil selected from the group consisting of Anise, Basil, Bergamot, Cannabis, Cardamom, Chamomile, Cinnamon, Cocoa, Cypress, Eucalyptus, Fennel, Frankincense, Geranium, Ginger, Ginkgo Biloba, Gotu Kola, Grapefruit, Hemp, Jasmine, Lavender, Lavandin, Lemon, Lemon Verbena, Lemongrass, Lime, Marjoram, Neroli, Nutmeg, Orange, Oregano, Peppermint, Pepper, Pine, Ravintsara, Rose, Rosemary, Sage, Spearmint, Tea Tree, Thyme, Turmeric, Vanilla, Ylang Ylang, and any other therapeutic plant essential oils, and combinations thereof, including any of one or more of the monoterpenes, sequiterpenes and/or diterpenes, and/or their alcohols, and/or aldehydes and/or esters normally found in any therapeutic plant essential oil, and combinations thereof.;
20. A bioactive composition comprising: at least one pharmaceutical compound; palmitoleic acid, wherein the ratio of palmitoleic acid to the at least one pharmaceutical compound in the bioactive composition is between 1 : 19 to 1000: 1 on a weight to weight basis; palmitic acid, wherein the ratio of palmitic acid to the at least one pharmaceutical compound in the bioactive composition is between 1 : 100 to 1000: 1 on a weight to weight basis; and oleic acid, wherein the ratio of the oleic acid to the at least one pharmaceutical compound in the bioactive composition is between 1: 100 to 1000: 1 on a weight to weight basis.

Summary

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