WO2019060986A1 – April 4, 2019 – CANNABINOID EXTRACTION PROCESS USING BRINE

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Inventors :

KO, Ryan Delmoral - c/o NextLeaf Solutions Ltd, 3-68 Schooner St, Coquitlam, British Columbia V3K 7B1; HUGHES, Brock - c/o NextLeaf Solutions Ltd, 3-68 Schooner St, Coquitlam, British Columbia V3K 7B1; PAL, Krupal Devendra - c/o NextLeaf Solutions Ltd, 3-68 Schooner St, Coquitlam, British Columbia V3K 7B1; SAMUELSSON, Alexzander - c/o NextLeaf Solutions Ltd, 3-68 Schooner St, Coquitlam, British Columbia V3K 7B1

Owner :

NEXTLEAF SOLUTIONS LTD

Application Number :

WOCA18051096

Document Number :

WO2019060986A1

Priority Date :

January 1, 1970

Filing Date :

September 7, 2018

Date of Grant/ Publication :

April 4, 2019

Class :

; A61K36 / 185; A61K31 / 05; A61K31 / 352; B01D11 / 02; C07C39 / 23; C07D311 / 80

Abstract

Raw cannabis plant material is mixed with ethanol and spun-dry to extract cannabinoids. The ethanol may be chilled before adding it to the raw cannabis plant material, and a non-polar solvent stage may be used to increase the yield of the extraction. The resulting crude oil and ethanol with the dissolved cannabinoids is separated from the raw cannabis plant material and filtered to remove particulates, waxes, lipids, fats and dissolved impurities. The ethanol is then evaporated from the resulting mixture of oil and ethanol, and the remaining oil then undergoes brine- washing, decarboxylation and distillation to obtain the cannabinoids and other desirable volatile phytochemicals.

Claim(s)

1 . A process for extracting cannabinoids from raw cannabis plant material comprising the steps of: adding ethanol to dried and ground cannabis plant material to form an initial mixture; spinning the initial mixture to separate a crude oil and ethanol mixture from the initial mixture; treating the crude oil and ethanol mixture with media to remove unwanted components therefrom; evaporating ethanol from the treated crude oil and ethanol mixture to leave oil; washing the oil with brine; decarboxylating the brine-washed oil to form decarboxylated oil; and distilling the decarboxylated oil to obtain cannabinoids.;
2. The process of claim 1 , further comprising the steps of: adding a non-polar solvent to the oil before washing the oil with brine; and evaporating the non-polar solvent after washing the oil with brine.;
3. The process of claim 2, wherein the non-polar solvent comprises hexane, heptane or pentane.;
4. The process of claim 2, further comprising, after washing the oil with brine and before evaporating the non-polar solvent, drying the oil with magnesium sulfate.;
5. The process of claim 2, wherein: the brine is 60-100% saturated with kosher sodium chloride; the step of washing with brine comprises agitating the non-polar solvent, oil and brine for 5-30 minutes; and the brine is removed by a centrifuge or gravity-fed separatory funnel.;
6. The process of claim 5, wherein the ratio of non-polar solvent to oil to brine is 1 : 1 :2.;
7. The process of claim 2, wherein the decarboxylating step comprises passing the brine-washed oil through a short-path film wipe apparatus.;
8. The process of claim 7, wherein the film wipe apparatus has: a feed temperature of 100-1 15°C; a residue discharge arm temperature of 100-1 15°C; an inner wall surrounded by a jacket with a circulating fluid at a temperature of 160-175°C; and a condensing coil temperature of 0°C to -20°C.;
9. The process of claim 2, wherein the decarboxylating step comprises heating the brine-washed oil to 90-1 10°C in a vacuum oven.;
10. The process of claim 1 , further comprising the steps of: drying the raw cannabis plant material; and grinding the raw cannabis plant material to result in the dried and ground plant material.;
1 1 . The process of claim 10, wherein the raw cannabis plant material is: dried to a moisture content of <15%; and ground to an average particle size of <9000???.; 12. The process of claim 1 , wherein the spinning step occurs in a wash and spin-dry separator and has a duration of 8-15 minutes.; 13. The process of claim 1 , wherein: the ethanol is at a temperature between -60°C and 18°C when it is added to the dried and ground cannabis plant material; and the ethanol is added to the dried and ground cannabis plant material in a ratio of 6.6-10 liters of ethanol to 1 kg of ground plant material.; 14. The process of claim 1 , wherein treating the crude oil and ethanol mixture comprises the steps of: adding charcoal particles to the crude oil and ethanol mixture, agitating the charcoal particles and crude oil and ethanol mixture, and filtering off the charcoal particles; then adding bentonite clay particles to the crude oil and ethanol mixture, agitating the bentonite clay particles and crude oil and ethanol mixture, and filtering off the bentonite clay particles; and then adding magnesium oxide particles to the crude oil and ethanol mixture, agitating the magnesium oxide particles and crude oil and ethanol mixture, and filtering off the magnesium oxide particles.; 15. The process of claim 14, wherein: filtering off the charcoal particles comprises filtering the charcoal particles and crude oil and ethanol mixture with a lenticular depth filtration apparatus; filtering off the bentonite clay particles comprises filtering the bentonite clay and crude oil and ethanol mixture with a lenticular depth filtration apparatus; and filtering off the magnesium oxide particles comprises filtering the magnesium oxide particles and crude oil and ethanol mixture with a lenticular depth filtration apparatus.; 16. The process of claim 15, wherein: the crude oil and ethanol mixture is at a temperature between -10°C and +85°C when charcoal particles are added; the charcoal particles are filtered off at a temperature between -10°C and 50°C; and the bentonite clay particles and the magnesium oxide particles are filtered off at a temperature between 10°C and 50°C.; 17. The process of claim 1 , wherein the unwanted components are one or more of pigments, chlorophyll, fats, waxes, lipids, heavy metals and particulates.; 18. The process of claim 1 , wherein the distilling step comprises: subjecting the decarboxylated crude oil to a first film wipe to remove volatile terpenes and leave a first residue; subjecting the first residue to a second film wipe to remove non-volatile terpenes and leave a second residue; and subjecting the second residue to a third film wipe to obtain cannabinoids.; 19. The process of claim 18, wherein: the first and second film wipes are performed at a pressure of 0.001 - 0.01 mbar; and the third film wipe is performed at a pressure of 0.0008 - 0.003 mbar.; 20. The process of claim 18, further comprising subjecting the cannabinoids to a further film wipe process to separate the cannabinoids into cannabidiol and tetrahydrocannabinol.; claim 21: 21 . The process of claim 18, wherein: the first film wipe is performed with: a feed temperature of 100-1 15°C; a residue discharge arm temperature of 100-1 15°C; an inner wall surrounded by a jacket with a circulating fluid at a temperature of 140-145°C; and a condensing coil temperature of 0°C to -20°C; the second film wipe is performed with: a feed temperature of 100-1 15°C; a residue discharge arm temperature of 100-1 15°C; an inner wall surrounded by a jacket with a circulating fluid at a temperature of 145-159°C; and a condensing coil temperature of 20-60°C; and the third film wipe is performed with: a feed temperature of 100-1 15°C; a residue discharge arm temperature of 100-1 15°C; an inner wall surrounded by a jacket with a circulating fluid at a temperature of 140-165°C; and a condensing coil temperature of 68-73°C.; claim 22: 22. The process of claim 1 , wherein the raw cannabis plant material is cannabis flower.; claim 23: 23. The process of claim 1 , wherein the raw cannabis plant material is cannabis leaves and stems.; claim 24: 24. The process of claim 1 , wherein the step of distilling is performed using a spinning band distillation apparatus.; claim 25: 25. The process of claim 1 , wherein the adding and spinning steps are performed simultaneously.; claim 26: 26. The process of claim 1 , further comprising leaving residual ethanol in the oil after the evaporating step, wherein the step of washing with brine removes the residual ethanol from the oil.; claim 27: 27. The process of claim 1 , wherein terpenes are obtained in the step of distilling.; claim 28: 28. The process of claim 18, further comprising subjecting the cannabinoids to a spinning band fractional distillation process to separate the cannabinoids into cannabidiol and tetrahydrocannabinol.

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