WO2019063848A1 – April 4, 2019 – SHORT PATH DISTILLATION IN VACUUM FOR ENRICHING NATURAL SUBSTANCES

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Inventors :

RUTZ, Andreas - Sonnenstr. 9, 91741 Dornhausen; ENGLERT, Michael - Peterstraße 37, 90478 Nürnberg

Owner :

BIONORICA ETHICS GMBH

Application Number :

WOEP18076699

Document Number :

WO2019063848A1

Priority Date :

September 30, 2017

Filing Date :

October 1, 2018

Date of Grant/ Publication :

April 4, 2019

Class :

; B01D3 / 12; B01D15 / 18; C07D311 / 80; B01D11 / 02

Abstract

The present invention relates to a method for producing, obtaining and enriching dronabinol (?9-THC) as well as natural substances from plant extracts.

Claim(s)

1. A process for the extraction of tetrahydrocannabinol from cannabis plant material, characterized in that a short-path vacuum distillation is carried out.;
2. From cannabis plant material of tetrahydrocannabinol extraction method according to claim 1, characterized in that the short-path vacuum distillation is effected by means of a short-path evaporator.;
3. A process for the extraction of tetrahydrocannabinol from cannabis plant material according to claims 1 or 2, characterized in that the short-path 10 cm, in particular 5 cm, in particular 2 cm, especially 0.5 cm between the evaporator and the condenser wall is.;
4. A process for the extraction of tetrahydrocannabinol from cannabis plant material according to any of the preceding claims, characterized in that the Short-path distillation column or separation column takes place by means of an additional vacuum.;
5. A process for the extraction of tetrahydrocannabinol from cannabis plant material according to claim 4, characterized in that the length of the separation column at least 2.50 m is.;
6. Process for the extraction of tetrahydrocannabinol from cannabis plant material according to any of the preceding claims, wherein the vacuum distillation at a first primary extract by weight with at least 15. 6~on The tetrahydrocannabinol takes place.;
7. Method for extraction from cannabis plant material according to any preceding of tetrahydrocannabinol, 0.001 to 50 mbar and the temperature wherein the pressure 120 to 240 degrees Celsius.;
8. Method for extraction from cannabis plant material of tetrahydrocannabinol, characterized in that one or more short-path distillation in vacuo with at least one liquid-liquid partition chromatography step before – – or is connected downstream.;
9. Method for extraction from cannabis plant material of tetrahydrocannabinol, characterized in that one or more short-path distillation in vacuo with at least one liquid-liquid partition chromatography step before – – or is connected downstream, wherein at least p.s.i.) a continuous change of stationary phase for mobile phase and vice versa held and/or II.) a solvent with a second immiscible liquid phase stationary by centrifugal force in the mobile phase.;
10. Tetrahydrocannabinol-containing extract according to any of claims 1 to 9, characterized in that the extract has a residue-free volatility.;
11. Drug, dietary supplements containing a tetrahydrocannabinol-containing extract obtainable by a process according to claims 1 to 9, in particular for inhalation.;
12. Process for the separation and/or purification of Natural substances from plant extracts, in particular of cannabinoids from a of cannabis extract, at least one liquid-liquid partition chromatography step -, wherein a containing Solvent with a second immiscible liquid phase is kept stationary by centrifugal force in the mobile phase and one or more Before short-path distillation in a vacuum – or be connected downstream, wherein one or more groups or one or more pure substances is/are separated.;
13. Process for the separation and/or purification of Natural substances from plant extracts, in particular of cannabinoids from a of cannabis extract, at least one liquid-liquid partition chromatography step -, wherein a containing the stationary phase is continuous change for mobile phase and one or more short-path distillation under vacuum and vice versa before – or be connected downstream, wherein one or more groups or one or more pure substances is/are separated.;
14. Process for the separation and/or purification of Natural substances from plant extracts according to one of Claims 13 and 12, characterized in that the fraction (s) of such classes Plant extracts selected from the group containing alkaloids, bitterness, anthocyanins, anthraquinones, coumarins, flavonoids, glucosinolates, lactones, lignans, lipids, cannabinoids, phenols, polyphenols, saponins, terpenes, Xanthone .;
15. Process for the separation and/or purification of Natural substances from plant extracts according to one of Claims 12 to 14, characterized in that at least one plant extract is selected from the group consisting of genera equiseti strain, Juglandis , Millefolii , qürcus, Taraxaci , althää, matricariä, Centaurium , Levisticum , Rosmarinus officinalis, angelic, the Artemisia, Astragalus , Leonurus , genera Salvia, Saposhnikovia , Scutellaria barbata, Siegesbeckia , Armoracia , Capsicum , Cistus , is Echinacea, Galphimia , Hedera , Melia is, from the leaves, of pelargonium, Phytolacca , a primula, Salix , thymic, castus, of Vitis, Rumicis , Verbena , Sambucus , Gentiana , of cannabis, is chosen.;
16. Process for the separation and/or purification of Natural substances from plant extracts according to claim 15, characterized in that at least one Plant extract selected species of equimolar (Horsetail herb) EIT herb, Juglandis Isatidis Folium (walnut sheets), herba ( Schafgarbenkraut ), Moutan cortex qürcus (oak bark), Taraxaci herb is selected from the group (Dandelion herb), Puerariae radix (marshmallow root) and matricariä althää ((chamomile flowers) carrying or chamomillä) carrying, Centaurium erythraea ( Tausendgüldenkraut ), Levisticum officinale ( Liebstöckel ), Rosmarinus officinalis officinal (Rosemary), angelic dahurica (Siberian Angelica, PinYin the name: Baizhi ), angelic sinensis to (Chinese Angelica, PinYin the name: Danggui ), the Artemisia scoparia (Broom-type wormwood, PinYin the name: Yinchen ), Astragalus astragalus ( Mongolicus thurigiensis var.) (tragacanth root, chinchin.: Huang agreed-to-SI), Leonurus japonicus ( Löwenohr , chinchin.: T üi), genera Salvia miltiorrhiza (red root and sage, chinchin.: Danshen ), Saposhnikovia (moremore siler, PinYin the name: catch to Feng), of Scutellaria baicalensis ( Baikal -helmet herb, Banzhilian ), Siegesbeckia pubescens (heavenly herb, the name divaricata PinYin : Xixianciao ), Armoracia rusticana ( Meerettich ), Capsicum (pepper). S.P., Cistus incanus ( Zistrose ), is Echinacea angustifolia to (sun hat), of Echinacea purpurea (sun hat), Galphimia glauca , Hedera helical (ivy), the Melia toosendan (Chinese elder fruits, chinchin.: Chuan Lian Zi is), from the leaves (olives) olea europea, S.P. of pelargonium. ( Pelagornien ), Phytolacca (pokeweed) of Americana, a primula veris (Primrose), Salix . S.P. (pasture), thymic n.l.l. (thyme), Agnus castus (monk pepper), Vitis (noble vine), Rumicis herb ( Sorrel tartly), Verbena officinale (iron herb), Sambucus nigral (black elder), Gentiana lutea (yellow gentian), of cannabis sativa glycoproteins (hemp), Silybum ( Mariendistel ).

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