WO2019087074A3 – September 6, 2019 – NEW CANNABIS COMPOSITIONS AND INDUSTRIAL METHODS FOR PRODUCTION THEREOF

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Inventors :

EYAL, Aharon - 16 Levy, 9362921 Jerusalem

Owner :

BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD

Application Number :

WOIB18058504

Document Number :

WO2019087074A3

Priority Date :

January 1, 1970

Filing Date :

October 30, 2018

Date of Grant/ Publication :

September 6, 2019

Class :

A61K31 / 05; A61K31 / 352; A61K36 / 185

Abstract

New cannabis compositions and industrial methods for production thereof. Homogeneous comminuted cannabis compositions comprising tetrahydrocannabinol and cannabidiol at selected weight/weight ratios, where at least 70 wt% of the comminuted cannabis plant material is of a size greater than 0.3 millimeter and less than 4.2 millimeters; the composition comprises at least 1wt% moisture and less than 20 wt% moisture; the tetrahydrocannabinol concentration in a 1 gram fraction of at least 10 gram sample of said homogeneous composition, is within 15% of the tetrahydrocannabinol concentration in a separate 1gram fraction of said 10 gram sample and the cannabidiol concentration in a 1 gram fraction of at least 10 gram sample of said homogeneous composition, is within 15% of the cannabidiol concentration in a separate 1gram fraction of said 10 gram sample.

Claim(s)

(1) 12-18wt% tetrahydrocannabinol and 0.01-6wt% cannabidiol; (m) 12-18wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (n) 12-18wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (o) 12-18wt% tetrahydrocannabinol and 18-24wt% cannabidiol; (p) 12-18wt % tetrahydrocannabinol and more than 24wt% cannabidiol;
(q) 18-24wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (r) 18-24wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (s) 18-24wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (t) 18-24wt% tetrahydrocannabinol and 18-24wt% cannabidiol; (u) 18-24wt % tetrahydrocannabinol and more than 24wt% cannabidiol;
(v) 24-30wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (w) 24-30wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (x) 24-30wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (y) 30-36wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (z) 30-36wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (aa) 30-36wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (bb) more than 36wt% tetrahydrocannabinol and 0.01 -3wt% cannabidiol;
(cc) more than 36wt% tetrahydrocannabinol and 3-6wt% cannabidiol; or (dd) more than 36wt% tetrahydrocannabinol and more than6wt% cannabidiol; (ii) at least 70 wt% of the comminuted cannabis plant material is of a size greater than 0.3 millimeter and less than 4.2millimeters; (iii) the composition comprises at least lwt% moisture and less than 20wt% moisture; (iv) the homogeneous composition, when separated into at least a 10 gram sample, contains a tetrahydrocannabinol concentration in a 1 gram fraction of the at least 10 gram sample within 15% of the tetrahydrocannabinol concentration in a separate lgram fraction of said at least 10 gram sample; and (v) and the homogeneous composition, when separated into at least a 10 gram sample, contains a_cannabidiol concentration in a 1 gram fraction of the at least 10 gram sample within 15% of the cannabidiol concentration in a separate lgram fraction of said at least 10 gram sample.;
2. The homogeneous composition of Claim 1, wherein tetrahydrocannabinol and cannabidiol concentrations are (a) more than 36wt% tetrahydrocannabinol and 0.01-9%wt cannabidiol; (b) 30-36 wt% tetrahydrocannabinol and 0.01-15wt% cannabidiol; (c) 24-30wt% tetrahydrocannabinol and 0.01-18wt% cannabidiol; (d) 18-24wt% tetrahydrocannabinol and 0.01-18wt% cannabidiol; (e) 12-18wt% tetrahydrocannabinol and 0.01-21wt% cannabidiol; (f) 6-12wt% tetrahydrocannabinol and 0.01 -24wt% cannabidiol; (g) 0.01-6wt% tetrahydrocannabinol and 0.01-34wt% cannabidiol; (h) 16-24 wt% tetrahydrocannabinol and l-7wt% cannabidiol (i) l l-18wt% tetrahydrocannabinol and 0.5-5.5 wt% cannabidiol; (j) 6-14wt% tetrahydrocannabinol and 0.2-3.8wt% cannabidiol; (k) 6-14wt% tetrahydrocannabinol and 6-14wt% cannabidiol; (1) 2.5-7.5wt% tetrahydrocannabinol and 6-14wt% cannabidiol; (m) 0.5-5.5wt% tetrahydrocannabinol and l l-18wt% cannabidiol; (n) 0.01-2.5wt% tetrahydrocannabinol and 16-24wt% cannabidiol; or (o) 0.01-0.5wt% tetrahydrocannabinol and 20-28wt% cannabidiol;;
3. The homogeneous composition of Claim 1, wherein the tetrahydrocannabinol comprises tetrahydrocannabinol and tetrahydrocannabmolic acid and wherein the weight per weight ratio between tetrahydrocannabinol and tetrahydrocannabmolic acid is in the range between 20 to 1 and 1 to 20.;
4. The homogeneous composition of Claim 1, wherein the cannabinol comprises cannabinol and cannabinolic acid and wherein the weight per weight ratio between cannabidiol and cannabidiolic acid is in the range between 20 to 1 and 1 to 20.;
5. The homogeneous composition of Claim 1, comprising less than lwt% cannabinol.;
6. The homogeneous composition of Claim 1, wherein at least 70 wt% of the cannabis plant material in said composition is derived from cannabis flower.;
7. The homogeneous composition of Claim 1, having a bulk density greater than 0.02 gram/milliliter.;
8. The homogeneous composition of Claim 1, having a bulk density less than 0.6 gram/milliliter.;
9. A cigarette containing the homogeneous composition of Claim 1.;
10. A vaporizer cartridge containing the homogeneous composition of Claim 1.;
11. A homogeneous tablet, comprising tetrahydrocannabinol (THC) and cannabidiol (CBD), wherein (i) tetrahydrocannabinol and cannabidiol and cannabidiol concentrations are: (a) 0.01 -6wt% tetrahydrocannabinol and 0.01-6wt% cannabidiol; (b) 0.01-6wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (c) 0.01-6wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (d) 0.01-6wt% tetrahydrocannabinol and 18-24wt% cannabidiol; (e) 0.01 -6wt% tetrahydrocannabinol and 24-28wt% cannabidiol; (f) 0.01-6wt% tetrahydrocannabinol and more than 28wt% cannabidiol; (g) 6-12wt% tetrahydrocannabinol and 0.01-6wt% cannabidiol (h) 6-12wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (i) 6-12wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (j) 6-12wt % tetrahydrocannabinol and 18-24wt% cannabidiol; (k) 6-12wt % tetrahydrocannabinol and more than 24wt% cannabidiol; (1) 12-18wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (m) 12-18wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (n) 12-18wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (o) 12-18wt% tetrahydrocannabinol and 18-24wt% cannabidiol; (p) 12-18wt % tetrahydrocannabinol and more than 24wt% cannabidiol; (q) 18-24wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (r) 18-24wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (s) 18-24wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (t) 18-24wt% tetrahydrocannabinol and 18-24wt% cannabidiol; (u) 18-24wt % tetrahydrocannabinol and more than 24wt% cannabidiol; (v) More than 24wt% tetrahydrocannabinol and 0.01 -6wt% (w) 24-30wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (x) 24-30wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (y) 24-30wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (z) 30-36wt% tetrahydrocannabinol and 0.01 -6wt% cannabidiol; (aa) 30-36wt% tetrahydrocannabinol and 6-12wt% cannabidiol; (bb) 30-36wt% tetrahydrocannabinol and 12-18wt% cannabidiol; (cc) More than 36wt% tetrahydrocannabinol and 0.01 -3wt% cannabidiol; (dd) More than 36wt% tetrahydrocannabinol and 3-6wt% cannabidiol; or (ee) More than 36wt% tetrahydrocannabinol and more than-6wt% cannabidiol;
(ii) said tablet moisture content is greater than lwt% and less than 20wt% ; (iii) said tablet bulk density is at least 0.1 gram/milliliter and less than 1.2 gram/milliliter;
(iv) the tetrahydrocannabinol concentration in a fraction of said tablet, is within 15% of the tetrahydrocannabinol concentration in a separate fraction of said tablet; (v) the cannabidiol concentration in a fraction of said tablet, is within 15% of the cannabidiol concentration in a separate fraction of said tablet; and (vi) said tablet comprises at least 70wt% cannabis plant material. 12. The homogeneous tablet of Claim 11, wherein tetrahydrocannabinol and cannabidiol concentrations are: (a) more than 36wt% tetrahydrocannabinol and 0.01 -9%wt cannabidiol; (b) 30-36wt% tetrahydrocannabinol and 0.01-15wt% cannabidiol; (c) 24-30wt% tetrahydrocannabinol and 0.01-18wt% cannabidiol; (d) 18-24wt% tetrahydrocannabinol and 0.01-18wt% cannabidiol; (e) 12-18wt% tetrahydrocannabinol and 0.01-21wt% cannabidiol; (f) 6-12wt% tetrahydrocannabinol and 0.01 -24wt% cannabidiol; (g) 0.01 -6wt% tetrahydrocannabinol and 0.01-34wt% cannabidiol; (h) 16-24wt% tetrahydrocannabinol and l-7wt% cannabidiol; (i) l l-18wt% tetrahydrocannabinol and 0.5-5.5wt% cannabidiol; (j) 6-14wt% tetrahydrocannabinol and 0.2-3.8wt% cannabidiol; (k) 6-14wt% tetrahydrocannabinol and 6-14wt% cannabidiol; (1) 2.5-7.5wt% tetrahydrocannabinol and 6-14wt% cannabidiol; (m)0.5-5.5wt% tetrahydrocannabinol and l l-18wt% cannabidiol; (n) 0.1-2.5wt% tetrahydrocannabinol and 16-24wt% cannabidiol; or (o) 0.1-0.5wt% tetrahydrocannabinol and 20-28 wt% cannabidiol.;
13. The homogeneous tablet of Claim 11, wherein the tetrahydrocannabinol comprises tetrahydrocannabinol and tetrahydrocannabmolic acid and wherein the weight per weight ratio between tetrahydrocannabinol and tetrahydrocannabmolic acid is in the range between 20 to 1 and 1 to 20.;
14. The homogeneous tablet of Claim 11, wherein the cannabinol comprises cannabinol and cannabinolic acid and wherein the weight per weight ratio between cannabidiol and cannabidiolic acid is in the range between 20 to 1 and 1 to 20.;
claim 14: 15. The homogeneous tablet of Claim 11, comprising less than lwt% cannabinol.;
claim 15: 16. A method for producing the homogeneous comminuted cannabis plant material composition, of Claim 1 comprising (i) providing a tetrahydrocannabinol-comprising cannabis plant material; (ii) providing a cannabidiol-comprising cannabis plant material; (iii) (a) comminuting each one of said tetrahydrocannabinol-comprising cannabisplant materials, and cannabidiol-comprising cannabis plant material whereby two separate comminuted homogeneous cannabis plant materials are formed, and/or (b) comminuting one of said tetrahydrocannabinol-comprising cannabis plant materials, and cannabidiol- comprising cannabis plant material, whereby a comminuted homogeneous cannabis plant materials is formed and extracting the non-comminuted cannabis plant material to form a cannabinoid-comprising extract; and (iv)(a) blending said two separate comminuted homogeneous cannabis plant materials of step (iii) (a) in a proportion calculated to form the said composition, and/or (b) blending said comminuted homogeneous cannabis plant material and said cannabinoid-comprising extract of step (iii)(b) in a proportion to form the said homogeneous comminuted cannabis plant material composition composition.;
claim 16: 17. The method of Claim 16, wherein said comminuting comprises (i) maintaining said provided cannabis plant material at a temperature of less than 0°C for at least 1 hour to form a frozen cannabis plant material; (ii) comminuting said frozen cannabis plant material by pressing against a mesh screen with a sieve size smaller than 4.2 millimeters to form expelled homogeneous composition comprising comminuted cannabis plant material; and (iii) collecting said expelled, homogeneous composition.;
claim 17: 18. The method of Claim 16, wherein said extracting comprises (i) optionally comminuting the non-comminuted cannabis plant material of step (iii)(b), whereby comminuted cannabis plant material is formed; (ii) contacting said non-comminuted cannabis plant material or said comminuted cannabis plant material with a liquid extractant for at least 1 minute to form cannabinoid-depleted plant material and a cannabinoid-comprising extractant, and (iii) separating said cannabinoid-depleted plant material from said cannabinoid-comprising extractant to form separated cannabinoid-comprising extractant.;
claim 18: 19. The method of Claim 18, comprising comminuting both said cannabis plant materials and blending said two comminuted cannabis plant materials with said cannabinoid-depleted plant material in a proportion calculated to form the said composition.;
claim 19: 20. The method of Claim 18, comprising blending said comminuted cannabis plant material and said cannabinoid-comprising extract with said cannabinoid-depleted plant material in a proportion calculated to form the said composition.;
claim 20: 21. The method of Claim 16, wherein at least 70 wt% of said provided tetrahydrocannabinol- comprises cannabis plant material and/or said provided cannabidiol-comprising cannabis plant material is derived from cannabis flower.;
claim 21: 22. The method of Claim 16, wherein said screen pore size is at least 0.3 millimeter.;
claim 22: 23. The method of Claim 16, wherein said provided tetrahydrocannabinol-comprising cannabis plant material, said provided cannabidiol-comprising cannabis plant material or both comprise less than 30% by weight moisture.;
claim 23: 24. The method of Claim 16, wherein said provided tetrahydrocannabinol-comprising cannabis plant material, said provided cannabidiol-comprising cannabis plant material or both comprise moisture at more than 1% by weight.;
claim 24: 25. The method of Claim 12, further comprising adding said homogeneous composition to a cigarettes tube or a cigarette paper, whereby a cigarette is formed.;
claim 25: 26. A cannabis cigarette produced according to the method of Claim 25, wherein said cigarette contains a top fraction and a bottom fraction and the concentration of tetrahydrocannabinol in a 0.1 gram sample from the top fraction of the cigarette is within 15% of tetrahydrocannabinol concentration in a 0.1 gram sample from the bottom fraction of the cigarette and wherein cannabidiol in a 0.1 gram sample from the top fraction of the cigarette is within 15% of cannabidiol concentration in a 0.1 gram sample from the bottom fraction of the cigarette.;
claim 26: 27. A batch of cannabis cigarettes produced according to the method of Claim 25, wherein the content of tetrahydrocannabinol in one third of the batch of the cigarettes is within 15% of the tetrahydrocannabinol content in a separate third of the batch of the cigarettes and wherein the content of cannabidiol in one third of the batch of the cigarettes is within 15% of the cannabidiol content in a separate third of the batch of the cigarettes.;
claim 27: 28. The method of Claim 16, further comprising pressing said homogeneous comminuted composition to form a homogeneous cannabis tablet.;
claim 28: 29. A homogeneous cannabis tablet produced according to the method of Claim 28, wherein said tablet has a bulk density of at least 0.1 gram/milliliter.;
claim 29: 30. A homogeneous cannabis tablet produced according to the method of Claim 28, wherein the tablet has a bulk density of less than 1.2 gram/milliliter.;
claim 30: 31. A homogeneous cannabis tablet produced according to the method of Claim 28, wherein the concentration of tetrahydrocannabinol in a fraction of said homogeneous cannabis tablet is within 15% of the tetrahydrocannabinol concentration in a separate fraction of the tablet and wherein the concentration of cannabidiol in a fraction of said homogeneous cannabis tablet is within 15% of the cannabidiol concentration in a separate fraction of the tablet.

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