WO2019106386A1 – June 6, 2019 – USE OF CANNABINOIDS IN THE TREATMENT OF EPILEPSY

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Inventors :

GUY, Geoffrey - GW Pharma Limited, Sovereign House, Vision Park, Chivers Way, Histon, Cambridge Cambridgeshire CB24 9BZ; KNAPPERTZ, Volker - GW Pharma Limited, Sovereign House, Vision Park, Chivers Way, Histon, Cambridge Cambridgeshire CB24 9BZ

Owner :

GW RESEARCH LIMITED

Application Number :

WOGB18053483

Document Number :

WO2019106386A1

Priority Date :

December 1, 2017

Filing Date :

November 30, 2018

Date of Grant/ Publication :

June 6, 2019

Class :

; A61K31 / 436; A61K31 / 05; A61K45 / 06; A61P25 / 08

Abstract

The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking immunosuppressant drugs. In particular the immunosuppressant drug is a calcineurin inhibitor. More particularly the immunosuppressant drug is tacrolimus. Where the CBD is used in combination with an immunosuppressant drug, caution should be taken. For example, the dose of either the CBD and / or the immunosuppressant drug may be required to be reduced. Moreover, the patient may need to be monitored for side effects of said drug-drug interaction. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

Claim(s)

1. Cannabidiol (CBD) for use in the treatment of childhood-onset epilepsy in patients who are concurrently taking an immunosuppressant drug characterised in that the blood levels of the immunosuppressant drug and associated markers are monitored to ensure the levels do not become toxic.

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