WO2019130201A1 – July 4, 2019 – PURIFIED CANNABIS EXTRACTS AND METHODS FOR PRODUCTION THEREOF

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Inventors :

EYAL, Aharon M. - 16 Levy ST,, 9362921 Jerusalem; BERNEMAN ZEITOUNI, Dana - 24 Tzur St., 4030000 Kfar Yona

Owner :

BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD

Application Number :

WOIB18060541

Document Number :

WO2019130201A1

Priority Date :

December 29, 2017

Filing Date :

December 21, 2018

Date of Grant/ Publication :

July 4, 2019

Class :

A61K36 / 185; A61K31 / 352; A61K31 / 05

Abstract

A method for producing a purified cannabis extract includes providing a first extract with an organic hydrophilic solvent, at least one cannabinoid, and water at concentration W 1 by weight, and at least one impurity at impurity to cannabinoid weight/weight ratio R1; adding water to the first extract to reach water concentration W 2 by weight, whereby a solid matter and a second extract are formed; separating the solid matter from the second extract, whereby separated solid matter and separated second extract are formed. The separated second extract includes the organic hydrophilic solvent, the at least one cannabinoid, and water to cannabinoid weight/weight ratio R 2 .

Claim(s)

1. A method for producing a purified cannabis extract comprising (i) providing a first extract comprising an organic hydrophilic solvent, at least one cannabinoid, water at concentration Wi by weight, optionally at least one terpene, optionally wax, and at least one impurity at impurity to cannabinoid weight/weight ratio Ri; (ii) adding water to said first extract to reach water concentration W2 by weight, whereby a solid matter and a second extract are formed;; (iii) separating said solid matter from said second extract, whereby separated solid matter and separated second extract are formed, wherein separated second extract comprises said organic hydrophilic solvent, said at least one cannabinoid, water, optionally at least one terpene and optionally said at least one impurity at impurity to cannabinoid weight/weight ratio R2; and optionally (iv) separating organic hydrophilic solvent from said second extract; wherein (a) the solubility of said organic hydrophilic solvent in water at 20°C is at least 20 gram solvent per 100 gram water; (b) W2/W1 is greater than 1.1; and (c) R2/R1 is less than 0.9.;
13. A method for producing a purified cannabis extract comprising (i) providing a cannabis plant material comprising at least one cannabinoid and at least one impurity at impurity to cannabinoid weight/weight ratio R3; (ii) contacting said cannabis plant material for a duration of at least 0.1 minute, with an extractant comprising an organic hydrophilic solvent and W3 water, wherein the temperature of said extractant is Ti, whereby a fourth extract and residual plant material are formed, which fourth extract comprises said organic hydrophilic solvent, at least one cannabinoid, water, optionally at least one terpene, optionally wax, and at least one impurity at impurity to cannabinoid weight/weight ratio R4; and (iii) separating said fourth extract from said residual plant material, wherein (a) said organic hydrophilic solvent is fully miscible with water at Ti and W3 is greater than 10% by weight, or the solubility of said organic hydrophilic solvent in water at Ti is at least 20 gram solvent per 100 gram water and W3 is at least one tenth of saturation water concentration at Ti; (b) Ti is sub-zero Celsius; and (c) R4/R3 is less than 0.9.

Summary

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